Disease-Modifying Treatments for Multiple Sclerosis Affect Measures of Cellular Immune Responses to EBNA-1 Peptides

L Dungan, J Dunne, M Savio, M Kalaszi… - Neurology …, 2024 - AAN Enterprises
activity (to complement existing measures such as MRI and clinic… other means of diminishing
the immune response to EBV. An … response to EBNA-1, we conducted univariate correlation

[HTML][HTML] Human herpesvirus 6 infection as a trigger of multiple sclerosis: an update of recent literature

KI Voumvourakis, PC Fragkou, DK Kitsos, K Foska… - BMC neurology, 2022 - Springer
… Latham et al. found that the increased antiviral immune responses, directed primarily …
significantly correlated with subsequent disease activity on Magnetic Resonance Imaging (MRI) …

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
… and prognostic criteria based on MRI and new biomarkers, … anti-EBV immune reactivity in
individuals with multiple sclerosis … CNS-targeted immune response in multiple sclerosis. EBV=…

Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells

A Gottlieb, HPT Pham, JG Saltarrelli… - Proceedings of the …, 2024 - National Acad Sciences
… initial infection with EBV (5, 6), and correlation of various markers of EBV activity with MS
disease … This is additional strong evidence for a role of the anti-EBV immune response in MS, …

Managing disease-modifying therapies and breakthrough activity in multiple sclerosis patients during the COVID-19 pandemic: toward an optimized approach

SM Hamdy, M Abdel-Naseer, HS Shehata… - … and Clinical Risk …, 2020 - Taylor & Francis
… -19 and the lack of specific anti-virus therapies, the current … the patient’s immune response,
raising uncertainties about the … ; yet, definite correlation between reduction of circulating …

An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis

X Yu, Z Zizzo, PGE Kennedy - Multiple Sclerosis and Related Disorders, 2021 - Elsevier
… (OCB) are the most characteristic features of multiple sclerosis (MS), a neuroinflammatory …
reduced clinical and magnetic resonance imaging (MRI) evidence of disease activity, although …

[HTML][HTML] The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
immune system due to its ability to establish a life-long latent infection in B cells, reactivate
periodically and induce a very effective immune response … damage positively correlates with …

[HTML][HTML] Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab

L Beckers, P Baeten, V Popescu, D Swinnen… - Clinical …, 2024 - Elsevier
… B cell depletion by the anti-CD20 antibody ocrelizumab is effective in relapsing-remitting (RR)
and primary progressive (PP) multiple sclerosis (MS). We investigated immunological

[HTML][HTML] A case of double standard: Sex differences in multiple sclerosis risk factors

B Angeloni, R Bigi, G Bellucci, R Mechelli… - International Journal of …, 2021 - mdpi.com
… sharper inflammatory pattern at magnetic resonance imaging (MRI) [11], … The aim of this
review is to analyze the possible correlation … between higher humoral antivirus response and the …

MINI-review of Epstein-Barr virus involvement in multiple sclerosis etiology and pathogenesis

F Aloisi, AH Cross - Journal of Neuroimmunology, 2022 - Elsevier
… as other factors influencing immune system function, including transient immunosuppression
due to stressful events or co-infections, could alter the immune response to EBV to favour …